MetaCore™ from GeneGo delivers high quality biological systems content in context, giving you essential data and analytical tools to accelerate your scientific research

MetaCore is an integrated software suite for functional analysis of microarray, metabolic, SAGE, proteomics, siRNA, microRNA, and screening data. MetaCore is based on a high-quality, manually-curated database of:

  • Transcription factors, receptors, ligands, kinases, drugs, and endogenous metabolites as well as other molecular classes
  • Species-specific directional interactions between protein-protein, protein-DNA and protein-RNA, drug targeting, and bioactive molecules and their effects
  • Signaling and metabolic pathways represented on maps and networks
  • Rich ontologies for diseases and processes with hierarchical or graphic output
Search and browse the content or upload experimental data to give it functional context and discover, validate, and/or develop new hypotheses for target selection and biomarker research with MetaCore.

With MetaCore, you can:

Peer-reviewed and manually curated by a team of Ph.D. and M.D. experts, the data contained within MetaCore is industry-leading in accuracy, reliability, and comprehensiveness.

With MetaCore you can:

  • Analyze any experimental high-throughput data in the context of pathways, networks, and maps
  • Identify and rank important pathways, networks, and disease terms for your lists of genes, proteins, transcripts, or compounds
  • Concurrently visualize and cross-validate different types of data
  • Apply disease, tissue, functional processes, and sub-cellular localization filters to focus networks on information relevant to the study

 

Why choose MetaCore?

MetaCore can significantly impact your research with:

  • Access to  the unrivalled biological systems content contained within  the MetaCore database
  • Robust data parsers and dynamic thresholding for comparative studies across any datasets
  • Interactome and topology tools that help avoid literature bias and rank molecular entities based on their connectivity for the dataset
  • Controlled vocabulary which provides one single semantic framework for all biological entities and their interactions
  • Rich proprietary ontologies that can be used for enrichment and functional profiling of multiple samples and various data types concurrently
  • Exporting and automated reporting capabilities that provide scientific workflow documents and network interactions and enrichments reports in minutes

You can also customize MetaCore to meet your specific needs with:

  • Custom network building with flexible and powerful algorithms and tools for easy network analysis
  • Custom ontologies for user-made networks that can be used for enrichments
  • Custom maps for hypothesis visualization and collaborative research
  • Custom interactions that can be introduced and juxtaposed over existing MetaCore interactions

PATHWAY ANALYSIS

  • Nearly 20 functional ontologies that can be used for filtering and enrichment, many of which are unique to MetaCore
  • Interactive canonical pathway maps capturing nearly 200,000 pathways
  • More than 1,000 complex formation and group relation schemas with species specificity

NETWORK ANALYSIS

  • Dozens of network generation options for any input lists or individual molecules
  • Proteins, genes, and compounds are represented as network objects; the only unique way to provide pathway continuity and account for localization- , fusion- , PTM, and complex- specific interactions
  • MetaCore exclusive algorithm for inclusion of known canonical pathways into any network for immediate high-level biological context serves as a GPS (or guide) in pathway analysis
  • Drug targets and therapeutic drugs available on networks and maps
  • Virtual knock-outs of individual nodes and combinations of nodes
  • Grow any network from any node and see the impact on enrichments and top hubs
  • Get a network report on topology, nodes and edges, local enrichments, and all interactions with references in 1 click

INTERACTOME ANALYSIS

  • Find major regulatory hubs significantly overconnected for any given list, experimental dataset, or between datasets

AUTOMATED WORKFLOWS WITH REPORTS

  • Compare experiments
  • Single experiment
  • Transcription target modeling
  • Receptor target modeling
  •  Transcription regulation
  • Biomarker assessment
  • Enrichment analysis
  • Tox workflow

EASY CONDITIONAL SEARCHING

  • Build focused conditional queries to answer your specific questions
  • Simple boolean-like search that can take you from systems biology level down to precise list of genes or drugs
  • Explore MetaBase with handy filters and a quick, powerful search engine
  • Flexible and intuitive categorical organization of searches and results
  • Narrow down to the most important answers that you can take from in-silico to the bench as reliable targets for experimental follow up

HARDWARE REQUIREMENTS

CLIENT (FOR WEB PORTAL AND IN-HOUSE INSTALLATIONS):

  • Mac (PPC or Intel) or Windows P4
  • 2GHz CPU and 1GB RAM recommended
  • Web browser: Internet Explorer version 6.0, Firefox 2.0, Safari 3.0.4 or higher
  • Macromedia Flash Player 8 or higher
  • Java Runtime Environment (JRE) 1.5.0

SERVER (FOR IN -HOUSE INSTALLATIONS):

  • 2 or more P4/XEON CPU’s with 4GB of RAM recommended
  • 3.2 GHz CPU and higher recommended
  • SCSI HDD with minimum of 250GB of storage is recommended
  • RAID recommended
  • RedHat Enterprise Linux 3, 4or 5.1; SuSE 9.2; CentOS 4.4
  • X development package installed
  • Oracle 10.2 DBMS and client tools
  • MetaCore supports x86-64bit architecture

MetaCore also has a range of optional modules, giving you extra data and tools to advance your research:

  • Data Annotation and Processing Tool – a user-friendly wizard that will manage, annotate, and statistically process our data in minutes.
  • Pathway Map Creator – a software tool for custom editing of existing canonical pathway maps, conversion of networks into map views for pathway analysis, and drawing regulatory and metabolic maps from scratch.
  • Systems Toxicology Module – a knowledge base and data analysis module designed for the assessment of safety liabilities of drugs, environmental contaminants, and other xenobiotics at all stages of discovery and development.

You also have the option of subscribing to additional pathway maps generated by partnerships with leading experts in the following areas, giving you further information and insight into your research:

  • Gastric Cancer
  • Hepatocellular Carcinoma
  • Huntingdon's Disease
  • Pancreatic Cancer
  • Prostate Cancer
  • Stem Cells

 

Contact Us

North America

Tel: +1 800.336.4474
Tel: +1 215.386.0100
Fax: +1 215.386.2911

Europe, Middle East & Africa

Tel: +44 20.7433.4000

Latin America

Brazil: +55 11 8370 9845
Other Countries: +1 215 823 5674

Japan

Tel: +81 3.4589.3100
Tel: 0800 888.8855 (free dial from Japan only)
Fax: +81 3.4589.3240

Asia Pacific

Australia & New Zealand:
     +61 2 8587 7636
China: +86 10 5760 1200
India: +91 11 3044 6419
Korea: +82 2 2076 8100
South East Asia & Pakistan:
     +65 6775 5088
Taiwan: +886 2 2503 3034

Additional Information

Factsheet 176 KB

Case Studies

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