Mechanism of Action
Solving a compound’s mechanism of action (MOA) is one of the most challenging task researchers face in drug discovery. As bioactive compounds have multiple, often pleiotropic effects on tissues and organs, a truly systemic experimental approach, comprehensive knowledge resources and analytical tools are needed.
Thomson Reuters can help. Manually curated databases and functional analysis toolkit will help to identify a compound’s primary and secondary targets, compare target profiles for multiple drugs, evaluate the effected disease pathology, toxicity and normal pathways, and generate executable MOA hypotheses.
- Comprehensive databases of biologically active agents and their targets will allow you to leverage known data to learn more about your novel compounds. MetaSearch Graphic >>
- Powerful chemo- and toxicogenomics workflows will complement your research to bring new hypotheses on how compounds work. MetaDrug Graphic >>
- Classical structure-based methods (metabolite prediction, structural alerts, QSAR modeling) will corroborate your hypotheses formulated by other approaches. Chemical Tools Graphic >>
- Experienced medicinal chemists, toxicologists, and disease biologists will help you to plan an experiment, solve mechanism of action based on your and public data, prioritize drug candidates, suggest alternative indications, and evaluate potential safety liabilities. Experts Graphic >>